https://docs.microsoft.com/en-us/microsoft-desktop-optimization-pack/appv-v5/about-app-v-51
App-V Version Reference
5.0 RTM 5.0.285.0
5.0 hotfix1 5.0.515.0
5.0 SP1 5.0.1104.0
5.0 SP2 5.0.3361.0
5.0 SP2 hotfix 2 5.0.3384.0 (Clients Only)
5.0 SP2 hotfix 4 5.0.3400.0
5.0 SP2 hotfix 5 5.0.3404.0 (Clients Only)
5.0 SP2 hotfix 6 ?
5.0 SP3 5.0.10107.0 (sequencer does not upgrade previous versions. The previous version must be removed first. Client version DOES upgrade.
5.1 client prereqs
.NET 4.5.1 required (KB2858728))
Powershell 3.0 (KB2506143) or higher
Windows 7 Update KB25333623 https://support.microsoft.com/en-us/help/2533623/microsoft-security-advisory-insecure-library-loading-could-allow-remot
5.1 sequencer prereqs
.NET 4.5.1 required (KB2858728))
Powershell 3.0 (KB2506143) or higher
5.1 HF08 sequencer prereqs
above plus KB25333623
update:
KB2533623 superceded by DB2758857
https://sccmentor.com/2013/07/30/kb2533623-superseded-by-kb2758857/
5.1 5.1.85.0
5.1 5.1.86.0
5.1 HF01 5.1.99.0 (CO = Clients Only)
5.1 HF02 5.1.101.0 (CO)
5.1 HF03 5.1.104.0 (CO)
5.1 June 2016 SR 5.1.106.0 (CO)
5.1 HF05 5.1.108.0 (CO)
5.1 Sept 2016 SR 5.1.115.0 (CO)
5.1 HF07 5.1.116.0 (CO)
5.1 HF08 Mar2017 SR 5.1.118 - Offline Client and Sequencers will need a certificate installed. Clients update, Sequencers full install.
Installing the HF08 sequencer (AppV5.1RTM_Sequencer_KB4014009.exe) can be a bit of a mission.
You must install the KB2533623 update first
If the sequencer is offline then you will need to install the Microsoft Root CA certificate.
How to export the MS Root CA certificate
https://support.microsoft.com/en-us/help/555252
From experience you can just double click and install but make sure you choose Trusted Root Certification Authorities.
How to install a root certificate.
https://msdn.microsoft.com/en-us/library/cc750534.aspx
More detailed client release / version info here
https://support.microsoft.com/en-us/kb/2940578
Tim's page is probably more up to date though
http://www.tmurgent.com/appv/en/resources/app-v-5-versions
Note that the Client UI application has its own version which does not correspond to the App-V Client version.
Windows 10 Anniversary Update version 1607 contains an App-V client which reports itself as 5.2 in the registry location
HKLM\SOFTWARE\Microsoft\AppV\Client\Version
General Microsoft End of Support information (End of Life)
https://support.microsoft.com/en-us/lifecycle/search
App-V 4.6 SP3 ended Mainstream support 14/07/2015
http://www.tmurgent.com/AppV/en/resources/app-v-4-versions
http://parlakyigit.net/ebooks/App_V_Versions.pdf
