App-V 5 App not launching / eventlog error

An App-V application fails to launch.  The following error appears in the App-V event log

Process 22004 failed to start due to Registry Staging subsystem failure. Package ID {187e5d55-af22-459e-bf2f-4ce9d9f7cbf5}. Version ID {cce01d5d-2ff0-4ae7-81bd-ce4ffa3d4936}. Error: 0x7D800D2A-0x3F1

Repair operations will not resolve this.

To fix this problem remove all the packages and connection groups associated with the application which is failing to launch.  Allow the deployment system to re-apply the App-V packages.